Stop COVID-19

AbbVie is partnering with global authorities to determine the effectiveness of HIV drugs lopinavir/ritonavir in treating COVID-19.

AbbVie is supporting clinical studies and basic research with lopinavir/ritonavir, working closely with European health authorities and the US FDA, Centres for Disease Control and Prevention, National Institutes of Health and the Biomedical Advanced Research and Development Authority to coordinate efforts.

AbbVie is not anticipating disruption to the medicine supply for HIV patients as a result of the investigation of the effectiveness of HIV medicines against COVID-19.

AbbVie announced a donation of $35 million to support COVID-19 relief efforts. In the US, AbbVie’s funds will be used to support healthcare capacity for hospitals as well as protect vulnerable populations by enabling access to food and essential supplies. In Europe, the donation will provide critical equipment and supplies to patients and front-line healthcare workers in the hardest-hit countries.

AbbVie announced donations to 26 nonprofit organizations totaling $5 million to support immediate COVID-19 relief efforts. Through support from the newly created AbbVie COVID-19 Community Resilience Fund, these organizations will help front-line healthcare workers and vulnerable populations in hard-hit communities.

AbbVie donated older antiviral drugs upon request from the Chinese government as an experimental option to support the growing public health crisis.

AIPM, uniting over 60 leading international pharmaceutical companies in Russia, is doing everything possible to coordinate the efforts of the industry and support the government to tackle the COVID-19 outbreak. In addition to accelerating efforts to develop diagnostic and therapeutic solutions, the Association and its member companies are working hard to prevent drug shortages and supply chain disruptions.

Under current circumstances, we focus on the following key areas:

1. Ensuring continuity and uninterrupted supply of all necessary drugs to the patients that need them;

2. Supporting comprehensive measures by the government and healthcare system in order to respond as quickly as possible to the challenges posed by the COVID-19 outbreak;

3. Accelerating the development of new vaccines, diagnostics and treatment for COVID-19, arranging conditions for fast registration thereof in the Russian Federation once successful therapeutic solutions emerge.

In order to ensure the fast availability of drugs for treating those suffering from COVID-19 and its complications and in order to plan and maintain uninterrupted supplies of all necessary drugs, the Association has come up with proposals to supplement the set of measures and tools developed by the Government, with measures that will allow for flexible monitoring, planning, production, and adaptation of regulatory requirements to minimize risks of shortages in drug provision to patients.

AIPM sent letters of appeal to government bodies: the Government of the Russian Federation, the Ministry of Health, the Ministry of Industry and Trade, Roszdravnadzor (Federal Service for Surveillance in Healthcare), realizing that amid tougher quarantine conditions, additional steps will be required to prevent a shortage of medicines in pharmacies and healthcare facilities, maintain the necessary supply regime, and create opportunities to quickly respond to the emerging needs of relevant government agencies. All this will allow regulators to concentrate as much as possible on solving other paramount tasks in the fight against the novel coronavirus pandemic.

The initiatives proposed by the Association include the following:

• providing of permissions to conduct clinical trials on the indication of COVID-19 in a priority (accelerated) order;

• introducing “conditional registration\ approval on conditions” on the COVID-19 indication and a simplified procedure for granting marketing authorization for COVID-19 medicinal products, vaccines, and diagnostics already approved in countries with strong regulatory systems;

• introducing a temporary moratorium on laboratory examinations and on-site inspections of pharmaceutical production facilities in order to confirm GMP compliance certificates provided that the applicant undertakes all necessary measures to carry out GMP inspections in the post-registration period;

• extending the transition period for the introduction of Trace&Track system for medicines until the COVID-19 pandemic has finished, the quarantine regime both in Russia and abroad has ended, and borders will be reopened so that professionals can travel;

• introducing a simplified procedure for introduction into civil circulation of priority medicinal products deemed essential for the treatment of patients suffering from the novel coronavirus and its complications, as well as for other medicines in high demand during the current pandemic;

• taking into account global restrictions on the supply of API and their auxiliary components, to establish procedure of urgent amendments to the registration dossier for the medicinal product which should be made by notification. This measure will allow for a quick substitution of an API supplier if there are any sudden changes should be adopted to supplying chains or if production facilities have to be changed;

• taking into account the growing dynamics of the COVID-19 pandemic that requires taking emergency and extraordinary measures on the part of stakeholders and the public healthcare system as a whole, consider giving an authorized federal healthcare executive body special powers to regulate the circulation of medicines;

• and others.

Amgen and Adaptive Biotechnologies (Seattle, USA) are partnering to combine expertise to discover and develop fully human neutralizing antibodies targeting SARS-CoV-2 to potentially prevent or treat COVID-19.

Amgen’s subsidiary deCODE genetics and colleagues from Iceland’s Directorate of Health and the National University Hospital published in the New England Journal of Medicine a population-based study of the early spread of SARS-Cov-2 (causing COVID-19 disease) in Iceland’s population.

Amgen and the Amgen Foundation announced an initial commitment of up to $12.5 million to support US and global relief efforts to address critical needs in communities impacted by COVID-19. The funds will be used to support emergency response efforts in Amgen’s US and international communities, patient-focused organizations that are mounting their own response efforts, and international relief efforts by Direct Relief and International Medical Corps.

To help support the cardiovascular community during this time, Amgen has donated $1 million to support the AHA’s COVID-19 rapid response efforts. Amgen’s donation will support a number of COVID-19-related initiatives, including the formation of the AHA COVID-19 patient registry will help improve the scientific community’s understanding of how the virus impacts cardiovascular health and better manage patients for improved health outcomes.

In Japan, Astellas is providing compounds in response to a request from the Ministry of Health, Labour and Welfare and National Institute of Infectious Diseases to cooperate in the “Basic Screening Plan for Drugs for Coronavirus Disease”.

Astellas is also responding to requests from the European Federation of Pharmaceutical Industries Associations (EFPIA) and the Innovative Medicines Initiative (IMI) to cooperate in “Activities Aimed at Developing Drugs for the Novel Virus” and providing consultation on countermeasures.

At Astellas there are currently no problems with the supply of products as we have been able to maintain an adequate inventory level of raw materials and finished products, by closely cooperating with outsourcing manufacturers and suppliers of raw materials taking into account the continuation of business and the stable supply of products.

Astellas announced Astellas Pharma US, Inc. and the Astellas Global Health Foundation are each expanding support for global and local communities fighting COVID-19 by providing up to $2 million of new financial assistance, in aggregate, to meet the urgent demand for resources to help patients, health care workers, and first responders.

In Italy, Astellas Pharma S.p.A., has decided on a donation worth 150,000 euros for the necessary supply of goods to public medical institutions and NPOs.

In Spain, Astellas Pharma S.A., has decided on a donation worth 200,000 euros to its country’s health ministry for the necessary supply of goods to medical institutions.
Furthermore, to assist health care systems coping with increasing demands by government or non-profit organization presented by the escalation of COVID-19 around the world, Astellas will authorize a maximum of 4 weeks of paid leave (in accordance with each country’s provision) to employees who are medically qualified and wishes to contribute in volunteer activities within their community.

Astellas Pharma China, Inc. donated one million yuan to the Red Cross Society of China for purchasing personal protective equipment (PPE) and procuring medical treatment equipment, next to a donation of  300,000 yuan worth of PPE, all for healthcare professionals serving at hospitals in Wuhan, China.

 AstraZeneca has mobilized its R&D expertise in infectious disease and antibody discovery technology to discover novel coronavirus-neutralising antibodies as a potential preventative treatment.

AstraZeneca’s R&D teams have identified monoclonal antibodies to progress towards clinical trial evaluation as a treatment to prevent COVID-19.

AstraZeneca will initiate a randomised, global clinical trial to assess the potential of Calquence (acalabrutinib) in the treatment of the exaggerated immune response (cytokine storm) associated with COVID-19 infection in severely ill patients. Calquence is approved for the treatment of adult patients with chronic lymphocytic leukaemia (CLL) in the US and a few other countries with an active global filing programme.

AstraZeneca and the University of Oxford are joining forces for the global development and distribution of the University’s potential recombinant adenovirus vaccine aimed at preventing COVID-19 infection from SARS-CoV-2. AstraZeneca received support of more than $1bn from the US Biomedical Advanced Research and Development
Authority (BARDA) for the development, production and delivery of the vaccine, starting in the fall. The development programme includes a Phase III clinical trial with 30,000 participants and a paediatric trial.

AstraZeneca – A Phase I/II clinical trial of AstraZeneca & Oxford University’s vaccine candidate began last month to assess safety, immunogenicity and efficacy in over 1,000 healthy volunteers aged 18 to 55 years across several trial centres in southern England. Data from the trial is expected shortly which, if positive, would lead to late-stage trials
in a number of countries.

AstraZeneca is accelerating the development of its diagnostic testing capabilities to scale-up screening and is also working in partnership with governments on existing screening programmes to supplement testing.

AstraZeneca is collaborating with GSK and Cambridge University by setting up a new testing laboraty at the University’s facilities for high throughput screening for COVID-19 testing. It will also explore the use of alternative chemical reagents for test kits to help overcome current supply shortages.

AstraZeneca and the University of Oxford joined forces to be responsible for the development, worldwide manufacturing and distribution of the vaccine, developed by the Jenner Institute and Oxford Vaccine Group, at the University of Oxford, if clinical trials prove successful.

AstraZeneca will make 30 million doses of coronavirus vaccine available to the U.K. by September and has committed to scale-up production to 100 million doses this year.
Astrazeneca – The Company has concluded the first agreements for at least 400 million doses of its vaccine candidate (being developed in collaboration with the University of Oxford) and has secured total manufacturing capacity for one billion doses so far and will begin first deliveries in September 2020. AstraZeneca is engaging with international organisations such as CEPI, GAVI and the WHO, for the fair allocation and distribution of the vaccine around the world. AstraZeneca is also in discussions with governments around the world to increase access. Furthermore, AstraZeneca is in discussions with the Serum Institute of India and other potential partners to increase production and distribution.

AstraZeneca is donating 9 million face masks to support healthcare workers around the world. It has partnered with the World Economic Forum’s COVID Action Platform, created with the support of the WHO, to identify countries in greatest need. Italy will receive the first shipments with other countries to follow.

AstraZeneca and GSK are collaborating to provide process optimisation support to various UK national testing centres for COVID-19 to expand testing capacity.

Bayer is supporting a French study conducted by medical experts to assess the effectiveness of a novel combination of molecules for the treatment of COVID-19 patients.

Bayer Canada will partner with the Population Health Research Institute (PHRI) to launch a major clinical research program with two studies that will evaluate the safety and efficacy of different combination therapies including Bayer’s chloroquine and interferon beta-1b. Bayer will make a financial commitment of CAD 1.5 million (approx. €1 million) towards the studies and will supply study drugs to support the research.

Bayer is making more than 40 virus diagnostics devices available from its research operations to scale up Germany’s COVID-19 analysis by several thousand tests daily. It is also freeing up specially trained personnel for this purpose.

Bayer is continuing the production of medicines and health care products at their plant in Garbagnate, Italy for both the Italian and global market.

Bayer made financial donations to an aid fund of the regional authorities in Lombardy, Italy to help procure urgently needed equipment for intensive care units in hospitals with the greatest needs.

Bayer started producing hand sanitizers in Cimanggis, Indonesia based on their expertise from their plants in Wuppertal and Bergkamen, Germany. Bayer is also supplying German hospitals with ventilators from their pharmacology labs and health care workers with masks. It also supports employees from the Pharmaceutical Division with a medical background to support the local health care system by offering them paid leave for 4 weeks. It is also providing the German Army with 600,000 chloroquine tablets.

Bayer made a donation of one million products to support the health of underserved US communities, including 3 million chloroquine tablets.

Bayer made a donation of €1 million (R$ 5.7 million) to combat COVID-19 in Brazil: €490,000 (R$ 2.8 million) is being contributed to the Brazilian government’s “Solidaric Fundraising” campaign, €350,000 (R$ 2 million) will go to UNICEF in Brazil to support children, youth projects and underprivileged communities and €160,000 (R$900,000) will enable the national health system to purchase personal protective equipment for hospitals (PPE).

Bayer made a donation of  €1 million to France to support the “All united against the virus” alliance set up by the Fondation de France, the Assistance Publique – Hôpitaux de Paris (AP-HP) hospital network and the Pasteur Institute.

Bayer already donated PPE, dermatological products and meals in the Lyon region.Bayer is donating approximately one million chloroquine tablets for COVID-19 treatment in Italy.

Bayer made substantial financial contributions as well as donations of several medicines to the Chinese Red Cross.

Bristol-Myers Squibb is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

 Bristol Myers Squibb (BMS) identified 1,000 compounds in its discovery library that they are making available to collaborators for screening for potential treatments for COVID-19. BMS is actively evaluating certain medicines in its portfolio that could be included in near-term clinical trials with a focus on agents impacting the inflammatory immune response associated with COVID-19.

Clinical and commercial supply chain teams at Bristol Myers Squib have proactively made sure raw materials and products reach their markets and clinical sites. It has not seen any disruption in its clinical or commercial supply chain due to the pandemic.

Bristol Myers Squibb (BMS) Company and the BMS Foundation donated more than $22 million in financial support and necessary products (e.g. PPE and medical eqiupment) to relief efforts in 40 countries. Licensed healthcare professionals employed by BMS are supported to volunteer in local hospitals and will continue to receive pay.

Through Skills2Give, an ongoing BMS volunteer program, colleagues in the US, UK and Australia have the option to select from virtual volunteer opportunities with thousands of nonprofit organizations. Over 3,000 employees are registered with the program.

The BMS Foundation has contributed to more than 40 patient advocacy groups and professional societies on the frontlines of patient care, and BMS is engaging with more than 250 patient and professional organizations to support research, education, patient psychosocial support and basic human needs. The BMS Foundation contributed a $7 million grant to Team Rubicon’s and Patient Advocate Foundation’s COVID-19 Emergency Food Assistance Program, which is providing assistance to immunocompromised patients whose ability to access or
afford food and other nutritional needs is at risk. BMS also partnered with GRYT Health to develop the COVID Advocacy Exchange, a virtual platform to unite patient advocacy organizations, patients, policy makers, healthcare practitioners and industry in the exchange of information.

Bristol Myers Squibb Company and the Bristol Myers Squibb Foundation are committed to supporting communities deeply affected by COVID-19. More than $5 million in financial support and needed products (i.e., personal protection equipment) has been provided to relief efforts in affected areas around the world, including Wuhan city and Hubei province (China).

Boehringer Ingelheim is searching for novel virus-neutralizing antibodies. It is also screening its entire molecule library for compounds that could target the virus.

Boehringer Ingelheim is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

Boehringer Ingelheim is contributing its ongoing COVID-19 projects and expertise to the Innovatie Medicines Initiative (IMI) of the European Union.

Boehringer Ingelheim supports scientists worldwide with its open innovation portal opnMe.com, which offers 6 anti-viral compounds out of 43 high quality pharmacological tool compounds at no cost for testing of research hypotheses.

Boehringer Ingelheim ensures further discovery, development, production and supply of highly innovative medicines that are needed by patients around the globe.

Boehringer Ingelheim contributes €5.8 million from their Global Support Program donations fund, provides paid leave for its 51,000 employees to volunteer for COVID-19 relief and established a €580,000 relief fund for social entrepreneurs and their communities in Kenya and India via its Making More Health program. Boehringer Ingelheim as also made a number of financial contributions totaling over $1 million to protect health care professionals in the critical services they are providing to patients.

Boehringer Ingelheim (BI) made financial donations to the Chinese Red Cross to purchase medical protective equipment and also made donations of medicines.

Chiesi Group will continue the production of all medicines without interruption at sites in Italy and abroad at the same high-quality standards. Currently, it is able to deliver medicines under normal production and distribution channels from all production plants in Italy, Brazil and France.

Chiesi Group commits €3 million for donations to support the ongoing emergency in Italy. It donated 50,000 units of sanitizing hand gel to public transport operators and personal protective equipment to hospitals. It collaborates with associations of general practitioners on advice and guidance, providing support for the purchase of respiratory equipment in hospitals that support COVID-19 patients.

CSL Group is collaborating with Takeda, Biotest AG, Bio Products Laboratory, LFB and Octapharma to accelerate development of an unbranded anti-SARS-CoV-2 polyclonal hyperimmune immunoglobulin medicine to treat COVID-19 patients with serious complications.

CSL Group is evaluating potential treatment candidates with SAB Therapeutics as part of its previously announced collaboration to investigate new therapies to treat infectious diseases as well as immunological and neurological conditions.

CSL/ Seqirus provides scientific and technical expertise together with its established MF59® adjuvant technology to the University of Queensland in Australia to fast-track R&D of their CEPI-funded COVID-19 vaccine candidate, which uses novel molecular-clamp technology.

Seqirus has enacted its business continuity plans across the globe to minimise disruption to the manufacture and on-time supply of its influenza vaccines.

CSL Limited donation of 1 million RMB to the China Red Cross in support of efforts to combat the pandemic.

Eisai is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

Eisai maintains necessary stocks for the stable supply of medicines in addition to the stable production of medicines.

In the US, Eisai has provided $250,000 in funding to non-profit patient organizations, in addition to providing Personal Protection Equipment to local healthcare providers.

In Europe, Eisai has provided €945,000 in funding to professional organizations such as the WHO, as well as to support healthcare providers and vulnerable communities in the UK, Italy, Germany, Spain, Belgium, France, Portugal, and Slovakia.

In Asian countries outside of China, Eisai has donated 11.8 million rupees to federal emergency funding in India,and is planning donations of funding and supplies in Indonesia, Thailand, the Philippines, Malaysia, and Vietnam.

Eisai has donated 1 million yuan to the Wuhan Charity Federation NPO and provided local healthcare providers with medicines and medical relief supplies.

Gilead is investigating the use of remdesivir (previously developed to treat Ebola, SARS and MERS).

Gilead announced that positive data is emerging from the National Institute of Allergy and Infectious Diseases’ (NIAID) study of the investigational antiviral remdesivir for the treatment of COVID-19.

Gilead has received EUA from the FDA for its potential COVID-19 treatment remdesivir.

Gilead received approval from the Japanese Ministry of Health, Labour and Welfare for Veklury® (remdesivir) for the treatment of adults and children with COVID-19.

 Gilead initiated two Phase 3 clinical trials of remdesivir in countries with high prevalence of COVID-19. The company is also supporting two Phase 3 trials in China and a global Phase 2 trial led by the US National Institute of Allergy and Infectious Diseases.

Gilead reports on the New England Journal of Medicine (NEJM) publishing an analysis of the effects of their investigational medicine remdesivir on a small group of patients with severe COVID-19 symptoms.

Gilead announces topline results from Phase 3 SIMPLE trial , NIAID releases positive interim findings from the Adaptive COVID-19 Treatment Trial (ACTT), and The Lancet publishes data and commentary from severe 2019-nCoV remdesivir clinical trial in China.

Gilead announced that findings from the NIAID trial of remdesivir in hospitalized patients with advanced COVID-19 have been published The New England Journal of Medicine (NEJM). These findings support the use of remdesivir in this population, with the largest benefit observed among individuals who required oxygen supplementation but were not mechanically ventilated.

Gilead also anticipates for results from their Phase 3 SIMPLE-Moderate study to be published at the end of May, and results from their Phase 3 SIMPLE-Severe study to be available in the near future.

Beyond the ongoing studies of remdesivir, Gilead is looking forward to the initiation of combination studies of remdesivir to understand whether the addition of other drugs may enhance patient outcomes.

Gilead has no manufacturing concerns or supply shortages with any Gilead products, including those in the HIV and hepatitis portfolios. Gilead’s global commercial supply chain is robust and resilient with the right processes in place, geographic diversity in the supply chain and enough of the materials required to make medicines.

Gilead does not anticipate shortages of Gilead marketed products, including HIV treatment or prevention medicines, in the foreseeable future. The supply network provides both flexibility and redundancy, and inventory levels are robust, with no immediate or foreseeable risk to our supply chain.

Gilead has accelerated manufacturing of remdesivir at risk, in anticipation of potential future supply needs.

Gilead has proactively scaled up manufacturing of remdesivir to increase available supply as rapidly as possible in anticipation of potential future supply needs. Gilead has increased supply nearly 30-fold since January and aims to produce more than 1 million treatment courses by year-end and several million in 2021, if required. These goals were based on a 10-day treatment course. The SIMPLE study results in patients with severe disease may enable significantly increasing the number of treatment courses using existing remdesivir supply.

To further expand global supply, Gilead is in discussions with leading chemical and pharmaceutical manufacturing companies about their ability, under voluntary licenses, to produce remdesivir for Europe, Asia and the developing world at least through 2022.

For the developing world, Gilead has negotiated long-term voluntary licenses with several generic drugmakers and is in active discussions with the Medicines Patent Pool to license remdesivir and with UNICEF to deliver the drug using its established distribution networks.

 Gilead has provided remdesivir to physicians for compassionate use to treat several hundred severely ill patients with confirmed COVID-19.

Gilead announced that their existing supply, including finished product ready for distribution as well as materials in the final stages of production, amounts to 1.5 million individual doses of remdesivir. This presents 140,000 treatment courses based on a 10-day treatment duration, all of which Gilead has committed for
donation.

Gilead announced a $20 Million Philanthropic Fund called Gilead CARES (COVID-19 Acute Relief and Emergency Support) Grantee Fund to support nonprofit organizations impacted by the COVID-19 Crisis. Organizations may be eligible to receive up to $100,000 in emergency assistance. Gilead will also make two significant community donations: $1 million to the San Mateo County Strong Fund and $1 million to the Mayor’s Fund for Los Angeles.

GSK and Vir Biotechnology Inc are in a collaboration using GSK’s expertise in functional genomics and Vir’s proprietary monoclonal antibody platform technology to accelerate existing and identify new anti-viral antibodies for use in therapeutics or preventative treatments.

GSK is starting trials of an experimental rheumatoid arthritis drug (otilimab) on patients suffering from severe pulmonary COVID-19 related disease by the end of May.

GSK is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

 GSK is collaborating with multiple companies and research groups on promising COVID-19 vaccine candidates through the use of its vaccine adjuvant technology, of particular  importance in a pandemic situation since it may reduce the amount of vaccine protein required per dose, allowing more vaccine doses to be produced and therefore contributing to protecting more people.

GSK entered into a collaboration with Sanofi to develop an adjuvanted vaccine for COVID-19, using innovative technologies from both companies. The vaccine is expected to enter clinical trials in second half 2020.

GSK is also collaborating with the University of Queensland, Clover Biopharmaceuticals and Xiamen Innovax Biotech Co., Ltd. GSK believes that more than one vaccine will be needed and is hoping that there will be a number of successful vaccines developed with its pandemic adjuvant technology.

GSK is partnering with AstraZeneca and Cambridge University to create a state-of-the-art, high-throughput testing laboratory in Cambridge, which is introducing state-of-the-art robotics,
automation and other diagnostic innovations to optimise COVID-19 testing. In the long-term, these innovations will inform and strengthen the UK’s diagnostics capability. For more details see AstraZeneca.

GSK is also conducting large-scale testing at its facility in Rixensart, Belgium.

GSK – GSK Consumer Healthcare is teaming up with Mammoth Biosciences to develop an accurate, easy-to-use, fully disposable, rapid and handheld test that consumers and healthcare providers in clinics can use to detect active SARS-CoV-2. The companies are aiming to have a device submitted for FDA Emergency Use Authorization (EUA) review before the end of 2020.

GSK has increased production of high demand products (e.g. multi-vitamins, respiratory medicines and antibiotics) and have so far donated more than 660,000 GSK products to more than 24 countries in Asia, Americas and EU.

 Under GSK and Sanofi vaccine development collaboration, both companies commit to create and supply sufficient quantities of vaccines that will help stop this virus. Both companies bring significant manufacturing capacity, and, if successful, they will be able to make hundreds of millions of doses annually by the end of next year.

GSK confirmed its intention to manufacture 1 billion doses of its pandemic vaccine adjuvant system, in 2021, to support the development of multiple adjuvanted COVID-19 vaccine candidates. GSK will manufacture, fill and finish adjuvant for use in COVID-19 vaccines at sites in the UK, US, Canada and Europe.

GSK is donating $10 million to the COVID-19 Solidarity Response Fund, created by the UN Foundation and WHO, to enable distribution of essential supplies such as personal protective equipment (PPE) to frontline health workers.

GSK is donating lab equipment, instruments, and scientific kits to support government testing and has donated over 700,000 PPE units to protect frontline health workers in 29 countries.

GSK joined forces with AstraZeneca to help expand UK testing capabilities. For more info see AstraZeneca.

Ipsen donated financial resources to the Institut Pasteur that has devoted a portion of its research, since January, to understanding SARS-CoV-2 in terms of epidemiology, biological characteristics and pathogenicity.

Ipsen is closely working with national and international supplies to monitor the provision of goods and services, with the goal of continuing operations as seamlessly as possible. It does not anticipate any supply shortages.

Johnson & Johnson, in partnership with the Rega Institute for Medical Research, University of Leuven (Belgium), are working to identify existing or new compounds with antiviral activity against COVID-19.

Johnson & Johnson is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

Johnson & Johnson expanded its collaboration with the Biomedical Advanced Research and Development Authority (BARDA) and established a new collaboration with Beth Israel Deaconess Medical Center (BIDMC).

Johnson & Johnson and partners announced the selection of a lead COVID-19 vaccine candidate from constructs it has been working on since January 2020. The Company has already begun preparations for clinical vaccine production at its facility in Leiden, the Netherlands, with the aim of initiating Phase 1 human clinical studies of its vaccine candidate in September 2020.

Johnson & Johnson entered into a research collaboration with Alveo Technologies to advance Alveo’s be.well™ platform of analyzers, nasal swabs and cartridges for the detection of viral
infectious diseases, including potentially SARS-CoV-2. J&J will provide Alveo with financial support as well as technical and regulatory counsel.

Johnson & Johnson announced a collaboration Emergent BioSolutions, Inc. to support the manufacturing of its lead investigational COVID-19 vaccine candidate. Johnson & Johnson has committed to rapidly produce and supply more than one billion doses of a safe and effective vaccine globally on a not-for-profit basis for emergency pandemic use.

Johnson & Johnson signed a deal with Catalent to accelerate rapid scale-up of segregated manufacturing capacity over the coming months to support dedicated production of Johnson & Johnson’s investigational vaccine candidate. Catalent plans to hire approximately 300 additional employees at the site for this program starting in July 2020 to meet operational readiness and 24×7 manufacturing schedules by January 2021.

Johnson & Johnson announced a $50 million commitment to support frontline health workers, especially doctors, nurses, midwives and community health workers who are working tirelessly to treat COVID-19 patients around the world.

Johnson & Johnson is encouraging medically trained employees to donate their time and expertise by joining the local health workforce in combating COVID-19. Medically trained employees worldwide can take a paid leave for up to 14 weeks through March 31, 2021. Any Johnson & Johnson employee or retiree who donates to the Covid-19 Solidarity Response Fund or the CDC Foundation’s All of Us Campaign will be matched by the company, dollar for dollar, up to a total match of $1 million for each organization.

Johnson & Johnson provided drug-screening for antiviral properties against the novel coronavirus to assist with laboratory-based investigations to the Chinese Centre for Disease and Prevention and donated 300 boxes of HIV medication to the Shanghai Public Health Clinical Centre and Zhongnan Hospital of Wuhan University.

LEO Pharma is participating in a pharma industry initiative supported by the European Commission to identify active compounds and compile a sample library for testing with the potential of reducing lead time for treatment development for COVID-19.

LEO Pharma has activated business continuity plans to uninterruptedly supply patients with the medicines they need. LEO Pharma is taking additional measures to avoid any shortages of medicines or raw materials and to mitigate any interruptions.

LEO Pharma has made donations to support local hospitals and communities in Northern Italy, Spain and the US states of New Jersey in their fight against COVID-19.

Eli Lilly and AbCellera (Canadian biotech firm) have agreed to co-develop antibody products for the treatment and prevention of COVID-19.

Eli Lilly and Junshi Biosciences have partnered to co-develop antibody therapies for the prevention and treatment of COVID-19. Lilly will receive an exclusive license to conduct clinical development, manufacturing and distribution of products outside of Greater China. Junshi Biosciences will maintain all rights in Greater China. Human trials could begin in the second half of 2020 in the United States of America and China.

Eli Lilly is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

Eli Lilly will advance its investigational selective monoclonal antibody LY3127804 against Angiopoietin 2 (Ang2) to Phase 2 testing in pneumonia patients hospitalized with COVID-19 who are at a high risk of progressing to acute respiratory distress syndrome (ARDS).

Eli Lilly is collaborating with Chugai on COVID-19 therapeutic antibodies, see Chugai for more details.

Eli Lilly has entered into an agreement with the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to study baricitinib as a potential treatment for hospitalized patients diagnosed with COVID-19. Baricitinib is approved in more than 65 countries as a treatment for adults with moderately to severely active rheumatoid arthritis.

Eli Lilly is participating in the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) partnership with the US National Institutes of Health (NIH) to speed up development of COVID-19 treatment options, streamline clinical trials, coordinate regulatory processes and/or leverage assets among all partners to rapidly respond to the COVID-19 and future pandemics.

Eli Lilly is participating in the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) partnership with the US National Institutes of Health (NIH) to speed up development of COVID-19 vaccine options, streamline clinical trials, coordinate regulatory processes and/or leverage assets among all partners to rapidly respond to the COVID-19 and future pandemics.

Eli Lilly launched the Lilly Insulin Value Program in the US allowing anyone with commercial insurance and those without insurance to fill their monthly prescription of Lilly insulin for $35.

Eli Lilly and AbCellera collaborate on AbCellera’s rapid pandemic response platform, developed under the DARPA Pandemic Prevention Platform Program, and Lilly’s global capabilities for rapid development, manufacturing and distribution of therapeutic antibodies.

Eli Lilly is deploying its medical professionals to staff a free drive-through COVID-19 testing facility at its corporateheadquarters in Indianapolis. The testing facility serves active frontline health care workers and first responders, asa service to the community and in an effort to protect people working on the front lines of this pandemic.

Eli Lilly and Company Foundation has contributed $500,000 to the Central Indiana COVID-19 Community Economic Relief Fund.

Lilly China made a cash donation of one million yuan (approximately $150,000) to the Red Cross, and the Lilly Foundation donated an additional $100,000 to Direct Relief, a US non-profit organization. In addition, the Lilly Foundation made a $150,000 donation to Project HOPE to help with their efforts in response to the Coronavirus.

Merck is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

Merck donated a supply of interferon beta-1a (Rebif®) to the French Institut National de la Santé et de la Recherche Médicale (INSERM) following a request for use in a clinical trial to investigate it as a potential therapeutic for COVID-19.

Merck is donating 290,000 units of its interferon beta-1a (Rebif®) to the WHO for use in their global SOLIDARITY trial which investigates several potential therapeutics for the treatment of COVID-19.

Merck and The Jenner Institute announced they have laid the foundation for large-scale production of The Jenner Institute’s COVID-19 vaccine candidate, ChAdOx1 nCoV-19. Their joint team reduced process development time to two months from a year.

Merck donated 150,000 liters of disinfectant to the German state of Hesse.

MSD is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

MSD and Ridgeback Biotherapeutics LP have entered into a collaboration agreement to develop EIDD-2801, an orally available antiviral candidate currently in early clinical development for the treatment of patients with COVID-19.

MSD and the US Institute for Systems Biology (ISB) are collaborating to investigate and define the molecular mechanisms of SARS-CoV-2 and COVID-19 and identify targets for medicines and vaccines, in partnership with US BARDA. Findings generated from the study will be made available to the worldwide scientific and biomedical community.

MSD and IAVI, a nonprofit scientific research organization dedicated to addressing urgent, unmet global health challenges, will work together to advance the development and global clinical evaluation of a SARS-CoV-2 vaccine candidate. This vaccine candidate will use the recombinant vesicular stomatitis virus (rVSV) technology that is the basis for MSD’s Ebola Zaire virus vaccine, ERVEBO®. The vaccine candidate is in preclinical development, and clinical studies are planned to start later in 2020.

MSD announced it will acquire Vienna-based biotech company Themis. The planned acquisition builds upon an ongoing collaboration between the two companies to develop vaccine candidates using the measles virus vector platform and is expected to accelerate the development of Themis’ COVID-19 vaccine candidate. The vaccine candidate is in pre-clinical development, and clinical studies are planned to start later in 2020.

Recognizing the changing needs of patients during the COVID-19 pandemic, MSD announced it is taking a number of new steps to support patients in the United States who may have lost their jobs and insurance coverage.

MSD has contributed or committed more than $30 million to COVID-19 relief efforts. Support includes donations of medicines, protective personal equipment (PPE) donations for health care providers and funding to relief organizations. A $10 million commitment will support COVID-19 relief efforts to help disparately impacted patients and communities in the U.S. and globally. A $3 million commitment, through MSD for Mothers, will help health systems better address critical maternal health needs during COVID-19. MSD also is enabling its medically trained employees to volunteer their time to aid their communities while maintaining their base pay.

MSD compiled a 1 million RMB donation for the Chinese Red Cross Foundation and supported the construction of a second specialty hospital (Leishenshan Hospital) to treat COVID-19 patients in Wuhan. Their team in China also launched online campaigns to educate the public about respiratory disease and helped provide up-to-date articles on treatment guidelines for health care professionals.

 Novartis is rapidly evaluating existing products to see if any could be utilized beyond their approved indications in response to the pandemic.

Novartis announced it would conduct a 450-person study in the US to determine if its malaria drug hydroxychloroquine can effectively treat COVID-19.

Novartis announced plans to initiate a Phase III clinical trial to study canakinumab in patients with COVID-19 pneumonia. The company aims to rapidly enroll 450 patients at multiple medical centers across France, Germany, Italy, Spain, UK and the US.

Novartis is co-chairing the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed of the development of therapeutics, but also vaccines and diagnostics for COVID-19.

Novartis is contributing by making several compounds from its libraries available that are considered suitable for in vitro antiviral testing.

Novartis plans to initiate a Phase III clinical trial in collaboration with Incyte to evaluate the use of Jakavi® (ruxolitinib) for treatment of a type of severe immune overreaction called a cytokine storm that can lead to life-threatening respiratory complications in COVID-19 patients.

Novartis and Incyte will take Jakafi into a second phase 3 trial for COVID-19 patients with acute respiratory distress syndrome (ARDS).

Novartis joins the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) initiative.

 Novartis‘ AveXis division is partnering with Massachusetts Eye and Ear and Massachusetts General Hospital, members of Mass General Brigham, entering into a manufacturing agreement to produce their novel genetic vaccine.

AveXis will begin manufacturing the vaccine this month while AAVCOVID undergoes further safety and efficacy testing in preclinical studies taking place at academic medical institutions including Mass. Eye and Ear.

Sandoz, the Novartis generics and biosimilars division, is maintaining prices on a basket of essential medicines that may help in the treatment of COVID-19.

Novartis encourages industry, governments and international institutions to work together to ensure adequate global access of medications to treat COVID-19 patients.

 Novartis commits to donate up to 130 million doses of hydroxychloroquine to support the global COVID-19 pandemic response. The Novartis COVID-19 Response Fund will provide $20 million to support communities around the world most impacted by the coronavirus pandemic.

Novartis and the Novartis US Foundation established a USD 5 million US COVID-19 Community Response Fund.

Novartis Canada and Sandoz Canada announced a donation of $500,000 to community and patient groups as part of the companies’ newly created Community Strong COVID-19 response program.

Novartis contributes $1 million to the International Rescue Committee to support the COVID-19 response in East Africa.

Novo Nordisk scientists are working in R&D laboratories to boost Denmark’s COVID-19 testing capacity.

Novo Nordisk is ensuring the supply of their lifesaving medicines to people with serious chronic diseases across the globe. Novo Nordisk is applying its experience with Chinese lockdown measures around the globe to assure continuity of their supply chain.

 Novo Nordisk is donating essential equipment including masks and gloves and provided 20 tonnes of alcohol to replenish stocks of hand sanitiser in hospitals. Novo Nordisk Foundation also made a donation of more than $7 million to fight COVID-19 in Denmark.

Pfizer finalised a preliminary assessment of certain antiviral compounds that were previously in development and that inhibited the replication of coronaviruses. Pfizer is working to  revive a compound identified as potential treatment for the 2003 SARS-CoV-1 which inhibits a specific enzyme (a protease) produced by coronaviruses.

Pfizer is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

Pfizer is committed to making the vital tools they develop available on an open source platform to the broader scientific community and to share data and learnings gained with other companies in real time to rapidly advance therapies and vaccines to patients.

Pfizer is committed to share their clinical development and regulatory expertise to support the most promising candidates smaller biotech companies bring forward.

Pfizer is reaching out to US federal agencies including NIH, NIAID and CDC to build a cross-industry rapid response team of scientists, clinicians and technicians able to move into action immediately when future epidemics surface.

Pfizer followed up on its commitments by sharing safety data on the Azithromycin-Hydroxychloroquine Combination.

Pfizer shared  preliminary data confirming the anti-SARS-CoV-1 compound shows antiviral activity against SARS-CoV-2. Pfizer will perform pre-clinical confirmatory studies, including further anti-viral profiling and assessment of the suitability of the lead molecule for IV administration clinically.

Pfizer and the Liverpool School of Tropical Medicine’s Respiratory Infection Clinical Research Group are launching two new studies to provide insights on the interaction between S. pneumoniae and SARS-CoV-2.

Pfizer and BioNTech have entered into a partnership to jointly develop BioNTech’s mRNA-based vaccine candidate BNT162 to prevent COVID-19 infection. The two companies plan to jointly conduct clinical trials initially in the United States and Europe across multiple sites by the end of April 2020. On April 22, the German regulatory authority, the Paul-Ehrlich-Institut, has approved the Phase 1/2 clinical trial for BioNTech’s BNT162 vaccine program to prevent COVID-19 infection.

Pfizer and BioNTech announced that the first cohort of BioNTech’s Phase 1/2 clinical trial has been dosed. Twelve study participants were dosed with vaccine candidate BNT162 in Germany since dosing began on April 23, 2020.

Pfizer and BioTNech announced that the first participants have been dosed in the U.S. in the Phase 1/2 clinical trial for the BNT162 vaccine program to prevent COVID-19. The Phase 1/2 trial in the U.S. will enroll up to 360 healthy subjects into two age cohorts (18-55 and 65-85 years of age).

Pfizer and BioNTech are jointly developing a COVID-19 vaccine, to be produced initially in the US and Europe. Manufacturing capacity will be scaled-up to support global supply. Pfizer will contribute its leading global vaccine clinical R&D, regulatory, manufacturing and distribution infrastructure and capabilities.

Pfizer is committed to use any excess manufacturing capacity and to potentially shift production to support others in rapidly getting life-saving breakthroughs into the hands of patients as quickly as possible.

Pfizer created a new Global COVID-19 Medical Service Program that empowers medical colleagues to provide diagnostic, treatment, and public health support.

Pfizer and the Pfizer Foundation announced a $40 million commitment in medical and charitable cash grants to help combat the COVID-19 pandemic. The donation addresses the urgent needs of partners who are working to slow the spread of the virus and strengthen vulnerable healthcare systems against future public health threats.

Pfizer has made cash contributions to its global NGO partners who have shipped supplies to hospitals in China.

Pfizer Foundation has provided $500,000 in grants to support the provision of urgently needed aid and supplies to front-line healthcare workers. This grant funding supports urgent assistance by Direct Relief and Project HOPE, who are working with local partners on the ground to provide supplies and other support to healthcare workers and health systems in affected areas of China.

Roche’s Actemra® was approved by China on March 5 to treat COVID-19 patients with lung complications. Actemra has been on the European market since 2010 for treatment of several kinds of arthritis.

Roche initiates phase III clinical trial of Actemra/RoActemra plus remdesivir in hospitalised patients with severe COVID-19 pneumonia.

 Roche is working with the US FDA to initiate a Phase III clinical trial to evaluate the safety and efficacy of Actemra in hospitalised adult patients with severe COVID-19 pneumonia. This is the first global study of Actemra in this setting and is expected to begin enrolling in early April hoping to attract 330 patients globally, including the US.

Roche (through its daughter company Chugai) announced it will initiate a randomized, double-blind, placebo-controlled Phase III clinical trial (COVACTA study) globally to evaluate the safety and efficacy of Actemra plus standard of care in hospitalized patients with severe COVID-19.

 Roche received Emergency Use Authorization (EUA) from the US FDA for its diagnostic kit cobas® SARS-CoV-2 Test. Roche is committed to delivering as many tests as possible and is going to the limits of production capacity.

Roche announced the development and upcoming launch of its Elecsys® Anti-SARS-CoV-2 serology test to detect antibodies in people who have been exposed to SARS-CoV-2.

Roche received EUA from the US FDA for its COVID-19 antibody test. Roche has already started shipping the new antibody test to leading laboratories globally and will ramp up production capacity to high double-digit millions per month to serve healthcare systems in countries accepting the CE mark as well as the U.S.

Roche is doing everything possible to ensure an adequate supply of their tests. It calls upon governments to work with the industry to keep global manufacturing and supplies running.

Roche is doing everything possible to ensure an adequate supply of their medicines. It calls upon governments to work with the industry to keep global manufacturing and supplies running by ensuring the free flow of vital goods across national borders, consider pragmatic temporary adjustments to regulations on packaging, reviews, customs etc. and to work together across governments internationally.

Roche’s subsidiary, Genentech and the Genentech Foundation are announcing charitable commitments of $42 million to help address the devastating impact of the COVID-19 pandemic. This support includes emergency response grants as well as funds for longer-term recovery efforts to mitigate ongoing challenges posed by the breadth and depth of this global health crisis.

Roche donated diagnostics tests, medical supplies and financial support. Genentech, a member of the Roche Group, is working with Chinese health authorities and the government to help provide screening and health care, including supporting local health officials and hospitals in the Hubei Province. Roche donated nearly $2m-worth of Actemra to China to help manage the COVID-19 outbreak.

Sanofi has entered into a partnership with Regeneron Pharmaceuticals to start a clinical program evaluating Kevzara in patients hospitalized with severe COVID-19. Kevzara, a drug originally used to treat arthritis, is a interleukin-6 (IL-6) pathway inhibitor which might help in slowing the overactive inflammatory response in the lungs of COVID-19 patients.

Sanofi is joining the COVID-19 Therapeutics Accelerator initiative, initiated by the Gates Foundation, Wellcome and Mastercard, to speed up the development of therapeutics, but also vaccines and diagnostics for COVID-19.

 Sanofi is coordinating with the Coalition for Epidemic Preparedness Innovations (CEPI) and sharing its vaccine R&D experience and expertise to advance vaccine solutions.

Sanofi commits to donating hydroxychloroquine (Plaquenil®) to governments worldwide if ongoing clinical trials demonstrate its safety and efficacy in COVID-19 patients.

Sanofi and Regeneron shared preliminary results from the Phase 2 portion of an ongoing Phase 2/3 trial evaluating Kevzara® (sarilumab) for treating hospitalized patients with “severe” or “critical” respiratory illness caused by COVID-19. In the preliminary Phase 2 analysis, Kevzara had no notable benefit on clinical outcomes when combining the “severe” and “critical” groups, versus placebo. The trial will now be amended so that only “critical” patients continue to be enrolled to receive Kevzara 400 mg or placebo.

Sanofi announced a collaboration with the Biomedical Advanced Research and Development Authority (BARDA) to advance a novel COVID-19 vaccine candidate. Work is underway to leverage previous development efforts of a SARS vaccine candidate using Sanofi’s recombinant DNA technology.

Sanofi, and Translate Bio, a clinical-stage messenger RNA (mRNA) therapeutics company, will collaborate to develop a novel mRNA vaccine for COVID-19. This collaboration leverages an existing agreement from 2018 between the two companies to develop mRNA vaccines for infectious diseases.

Sanofi joined forces with GSK, sharing innovative technologies from both companies. For more details see GSK.

Sanofi joined forces with Luminostics to develop a COVID-19 smartphone-based self-testing solution. Luminostics would contribute its proprietary technology for consumer-diagnostics for COVID-19 testing while Sanofi would bring its clinical research testing experience and capabilities.

Sanofi to provide hydroxychloroquine (Plaquenil®) wherever possible and will secure appropriate supply levels of current approved indications.

Sanofi increased production capacity of hydroxychloroquine (Plaquenil®) by 50% and is on track to further increase production over the coming months.

Under Sanofi and GSK vaccine development collaboration, both companies commit to create and supply sufficient quantities of vaccines that will help stop this virus. See GSK for more details.

Sanofi announced it will make a charitable gift of 100 million euros to help tackle the coronavirus crisis in France, with the money going to hospitals, care homes and other initiatives.

Sanofi will donate 100 million doses of hydroxychloroquine across 50 countries.

Servier puts its best efforts forward to ensure the continuity of its production in order for its medicines to remain available to patients who rely on them. It therefore brings its expertise to the multi-stakeholder partnership “Health Innovation Coalition – Health Crisis” in France.

Servier actively contributes by providing personal protection equipment to hospitals in affected countries, as well as making donations to foundations and NGOs (e.g.: Chinese Red Cross and APHP Foundation). In addition, tens of healthcare professionals employed by Servier have volunteered and have been made available to French health authorities to join medical staff on the front line against SARS-CoV-2.

Takeda and CSL Group formed the CoVIg-19 Plasma Alliance with other leading global plasma companies, including Biotest, BPL, LFB and Octapharma, to develop a potential plasma-derived therapy for treating COVID-19. The Alliance is developing a medicine made from the plasma of individuals who have recovered from COVID-19 with the potential to treat those at risk of serious conditions form COVID-19. The CoVIg-19 Plasma Alliance has since expanded to comprise 10 companies and attracted the support of major companies and organizations.  It is expected that this will enhance both speed and scale.

Takeda partnered with IMI in Europe to leverage collective expertise in the hope to develop inhibitors to help prevent future outbreaks.

Takeda and the CoVIg-19 Plasma Alliance partnered with the US National Institute of Allergy and Infectious Diseases (NIAID) for a global study on the safety, tolerability and efficacy of the hyperimmune therapy in adult COVID-19 patients. The study is anticipated to start in the summer and will form the foundation for potential regulatory approval.

Takeda is partnering with public entities and other pharmaceutical companies through the Innovative Medicines Initiative (IMI) in Europe to leverage collective expertise in the hope of developing diagnostics for COVID-19.

Takeda is currently not experiencing any potential supply disruption due to the Coronavirus outbreak. The company is tracking the situation as it evolves and will take all necessary actions in an effort to ensure supply continuity for patients.

Takeda is in total donating $6.25 million to the American Red Cross, the city of Cambridge, and the town of Lexington to fight COVID-19. The Red Cross will receive $4 million to make sure the organization can maintain a sufficient blood supply during the health crisis. Takeda is donating $2 million to the Cambridge Mayor’s Relief Fund and $250,000 to the Lexington Emergency Assistance Fund to help families affected by the epidemic.

Teva is actively looking through its range of products to determine if it can help provide any products that may be relevant in addressing acute and substantial need during the COVID-19 crisis.

Teva is prepared for various scenarios and has inventory and redundancy plans in place to address potential shortfalls, if necessary. The supply chain for their key products, brand, generics and APIs remains largely uninterrupted with adequate inventory of products.

Teva is assessing additional production of hydroxychloroquine sulfate tablets with materials that are being sent to Teva from its ingredient supplier.

Teva’s global manufacturing network has been working tirelessly on securing and scaling production of both API and finished doses for potential treatments that my prove essential in treating COVID-19 everywhere Teva does business.

Teva donated more than 10 million hydroxychloroquine doses to hospitals and refocused their Mount Sinai partnership. In Israel, it donated 2 million hydroxychloroquine units to the Israeli Ministry of Health, supported government-led programs and supported the National Aid Society. In India, it provided personal personal protective equipment (PPE), kits and food to populations in need. To Spain, it donated hydroxychloroquine and PPE.

In the UK, it employees are able to volunteer with the National Health Service (NHS) without having to use unpaid leave.

Teva donated 9,600 packs of azithromycin to 15 hospitals in Hubei.

UCB is working with the US-based Seattle Structural Genomics Center for Infectious Disease to identify crystal structures of SARS-CoV-2 proteins. It is also partnering with UK-based Diamond Light Source and The University of Oxford to design inhibitors of SARS-CoV-2’s main protease for treatment of COVID-19 patients. It is also working with government agencies and the healthcare community to determine if any of their therapies could be used effectively against COVID-19.

UCB is collaborating with The University of Oxford on a vaccine development.

UCB is working closely with the Belgian government to scale up COVID-19 testing capabilities. It is looking at similar possibilities in the UK.

UCB is assuring a reliable supply of medicines in every market it has a commercial presence in. It has not experienced shortages for any of our products due to this epidemic.

UCB is donating hydro-alcoholic solutions to the Belgian and Swiss authorities which it started producing at its own major manufacturing sites. It is further supporting healthcare professionals in its company that wish to volunteer in line with local government needs and guidance. It also donated masks and googles to Belgian healthcare authorities and local hospitals.

UCB is collaborating with The University of Oxford on a vaccine development.